Spectinomycin: minimum inhibitory concentrations for Neisseria gonorrhoeae.

Spectinomycin: minimum inhibitory concentrations for Neisseria gonorrhoeae.

Actinospectacin, a broad-spectrum antibiotic derived from Streptomyces spectabilis, was released for clinical trials more than 10 years ago. Although it possesses activity against many micro-organisms, both Gram-positive and Gram-negative, its use has been limited mainly to the treatment of gonorrhoea. Its efficacy in the treatment of this disease has been reported by a number of investigators....

Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae--California.

Testing sensitivity of Neisseria gonorrhoeae to spectinomycin.

A concentration of 16 mg/l spectinomycin incorporated in agar gave the best discrimination between Neisseria gonorrhoeae sensitive and resistant to spectinomycin. This method was compared with spectinomycin sensitivity testing with 25 micrograms or 100 micrograms discs. Both methods agreed fully for 197 spectinomycin sensitive and three spectinomycin resistant gonococci. The agar incorporation ...

Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae.

Since March 1976, 7 cases of PPNG have been identified in Alaska. However, 3 of these cases occurred in 1980. We recommend that all physicians and other health care providers be alert for any patient diagnosed as having gonorrhea who gives a history of exposure in Southeast Asia or the Philippines. Such patients should be cultured, the lab slip marked "test for possible PPNG", and treatment giv...

Streptomycin and Spectinomycin in Neisseria gonorrhoeae

A cell-free protein synthesizing system was used to study the mechanism of resistance to streptomycin (Str) and spectinomycin (Spc) in laboratory mutants and clinical isolates of Neisseria gonorrhoeae. The 70S ribosomes from sensitive strains were sensitive to the effects of Str and Spc on synthesis directed by several synthetic polynucleotide messengers, whereas 70S ribosomes from resistant st...